4D-150 is being evaluated in the currently-enrolling PRISM clinical trial, a Phase 1/2 dose-escalation and randomized, controlled, masked expansion study of intravitreal 4D-150 in adults with wet AMD. The primary endpoints of the study are safety and tolerability. Secondary endpoints include the number of supplemental aflibercept injections over 52 weeks, change from baseline in best corrected visual acuity (BCVA) over time and central subfield thickness (CST) measured by SD-OCT.
4D-150 will be evaluated in the SPECTRA clinical trial, a Phase 2 randomized, active-controlled, double-masked study of intravitreal 4D-150 genetic medicine in adults with DME. The primary endpoint of this study is the annualized number of aflibercept injections in the study eye. Secondary endpoints include change from baseline in BCVA, CST and percentage of subjects with improvement in diabetic retinopathy severity scale. Enrollment is anticipated to begin in Q3 2023.
4D-125 is being evaluated in the EXCEL clinical trial, a Phase 1/2 dose-escalation clinical trial in patients with XLRP related to mutations in the RPGR gene. The primary endpoint of this trial is to determine the safety and maximum-tolerated dose. Secondary endpoints include assessments of biological activity, including both visual field function and anatomical endpoints.
4D-110 is being evaluated in the CHORUS clinical trial, a Phase 1/2 dose-escalation clinical trial in patients with choroideremia related to mutations in the CHM gene. The primary endpoint of this trial is to determine the safety and maximum-tolerated dose. Secondary endpoints include assessments of biologic activity, including visual acuity, visual field function and anatomical endpoints.
The urgent mission of the Foundation Fighting Blindness is to drive the research that will provide preventions, treatments and cures for people affected by retinitis pigmentosa, macular degeneration, Usher syndrome and the entire spectrum of retinal degenerative diseases
Language courtesy of Foundation Fighting Blindness
The Choroideremia Research Foundation (CRF) is the largest organization in the world focused on the search for a cure for choroideremia (CHM). Their mission is to raise funds in support of scientific research leading to a treatment or cure of choroideremia, a hereditary retinal-degenerative disease that causes blindness; to educate people affected by the disease; and to inform the public.
Language courtesy of Choroideremia Research Foundation