Genetic Medicines with Curative Intent

Our Commitment to Patients

The definition of “advocate” is “to support a cause or proposal.” We believe that truly advocating for patients and families requires much more than “support.” It requires commitment, dedication, compassion and listening to ensure we are continually doing what is right for patients, their families and the greater community. We seek to inspire and lift up the advocates who work tirelessly to shine a light on debilitating diseases and conditions.

At 4DMT, our priority is to weave the patient perspective into the fabric of our work and daily activities. We believe in the importance of collaborating closely with patients, their families, patient advocacy organizations, physicians, researchers and regulatory authorities to educate on the work we are doing. We seek to advance our overall understanding of the diseases we treat, including the unmet patient needs that exist for each disease.

Ophthalmological Diseases

Wet Age-Related Macular Degeneration (Wet AMD)

Neovascular age-related macular degeneration (wet AMD) is a type of age-related macular degeneration where abnormal blood vessels (choroidal neovascularization or CNV) grow into the macula, the central area of the retina. As a result, CNV causes swelling of and fluid retention in the retina, bleeding and scarring, and causes blurry vision and reduced ability to see small details. The ongoing leaking of the abnormal blood vessels is stimulated by vascular endothelial growth factor otherwise known as VEGF. This process distorts and can potentially destroy central vision and may progress to blindness without treatment. Wet AMD is typically treated with intravitreal anti-VEGF agents administered approximately every 4-12 weeks.

Diabetic Macular Edema (DME)

People who have type 1 or type 2 diabetes may develop a complication called diabetic retinopathy or damage to the small blood vessels of the eye’s retina that can lead to vision loss. Diabetic macular edema (DME), which is associated with diabetic retinopathy and progresses faster, occurs when fluid from these damaged blood vessels leaks into the macula — an area in the center of the retina that helps us see objects directly ahead of us — which causes swelling of the retina and is also associated with vision loss. DME is typically treated with intravitreal anti-VEGF agents administered approximately every 4-12 weeks.

About 4D-150 for the treatment of wet AMD & DME

Ophthalmology Clinical Trials

4D-150 is being evaluated in the currently-enrolling PRISM clinical trial, a Phase 1/2 dose-escalation and randomized, controlled, masked expansion study of intravitreal 4D-150 in adults with wet AMD. The primary endpoints of the study are safety and tolerability. Secondary endpoints include the number of supplemental aflibercept injections over 52 weeks, change from baseline in best corrected visual acuity (BCVA) over time and central subfield thickness (CST) measured by SD-OCT.

4D-150 will be evaluated in the SPECTRA clinical trial, a Phase 2 randomized, active-controlled, double-masked study of intravitreal 4D-150 genetic medicine in adults with DME. The primary endpoint of this study is the annualized number of aflibercept injections in the study eye. Secondary endpoints include change from baseline in BCVA, CST and percentage of subjects with improvement in diabetic retinopathy severity scale. Enrollment is anticipated to begin in Q3 2023.

Clinical Trial Programs

Learn more about our ongoing clinical trials, find disease education information, and get to know our advocacy partners:

Ophthalmic Diseases

Pulmonary Diseases

Cardiovascular Diseases

Stay informed

Clinical Trial Email Sign Up

Register below to receive updates on our clinical trial programs and other patient advocacy initiatives.

"*" indicates required fields



Treating physicians, patients and caregivers interested in learning more about 4DMT’s investigational genetic therapies currently in clinical studies (trials) can find more information at

If you are a patient or caregiver interested in one of our clinical trials, talk with your treating physician to see if you may be a candidate. For all other inquiries, please contact Patient Advocacy at